While it seemed possible that the injury could have been part of the storyline, perhaps to soften Mysterio up and make him look vulnerable prior to facing United States champion Samoa Joe at WrestleMania 35 on Sunday, Dave Meltzer has confirmed that the ankle injury is legitimate.
The ankle injury necessitated in cancelling Mysterio's scheduled match with Andrade on SmackDown this past Tuesday night. Meltzer added in his Wednesday edition of The Wrestling Observer, "At press time we don’t know about WrestleMania."
In WWE.com's report of the injury, it was noted that Mysterio would continue to be evaluated prior to WrestleMania 35
Mysterio wrote in his Instagram video of the injury, "Praying to be ready for Mania this Sunday!"